Stress and psoriasis are closely linked, with each capable of worsening the other. Stress can trigger or exacerbate psoriasis flare-ups by activating the immune system and increasing inflammation, while the chronic discomfort and visibility of psoriasis can lead to emotional distress, low self-esteem, and anxiety. This creates a cycle where stress worsens symptoms and psoriasis contributes to further stress. Biologically, this connection is driven by the stress response system, particularly the Hypo-thalamo-pituitary axis, which affects immune regulation. Managing both stress and psoriasis is key and may involve stress-reduction techniques like mindfulness, therapy, and exercise, alongside medical treatments such as topical therapies, biologics, or light therapy. A holistic approach often provides the best results.